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蛋白质含量确定你们# 8217的金发或深色的研究显示

发布时间:2018-09-27 文章编辑:admin

A study from the Stanford University School of Medicine has found that certain protein levels determine whether you’;re a blonde or a brunette。

For the first time, the molecular basis for one of the most important physical human traits was described, outlining that even the tiniest DNA changes could have a crucial impact on our genome, which has possibly affected the evolution, the migration and even the course of the history as we know it today。 David Kingsley, PhD and expert in developmental biology, declared that:

‘We’;ve been trying to track down the genetic and molecular basis of naturally occurring traits —; such as hair and skin pigmentation —; in fish and humans to get insight into the general principles by which traits evolve, and now we find that one of the most crucial signaling molecules in mammalian development also affects hair color。’

A protein called KITLG, commonly known as a stem cell factor, was found to be encoded in the genes whose expressions are regulated in the DNA。 Turns out that a single change in the DNA according to this biological procedure is responsible for major physical traits, such as the predominantly blond hair of Northern Europeans。  This change was found to affect only the level of KITLG in hair follicles。

Another result of the study concerns the tissue-specific, small changes in the expression of genes, whose effect can be morphologically noticeable。 Connecting specific DNA changes with specific clinical prototypic outcomes is clearly laborious, as the study conducted by David Kingsley and led by Cathrine Guenther (PhD) underlines。 To be more specific, the change is called ‘subtle’ because it occurs over 350, 000 nucleotides away from the KITLG gene itself and its impact on the amount of gene expression is no bigger than 20 percent。 The procedure involves replacing an adenine (a single nucleotide) by a guanine on human chromosome 12 and its impact is believed not to be significant, taking into consideration that, when it comes to gene expression, the scale is only referred to as ‘on’ or ‘off’。

本文源自: 环亚娱乐